【2024年度】

＜タイトル＞

The appropriate conditions for the cell sparing (FLASH) effect exist in ultra-high dose rate carbon ion irradiation

＜著者＞

Kazumasa Minami, Masashi Yagi, Kazuki Fujita, Kana Nagata, Ryo Hidani, Noriaki Hamatani, Toshiro Tsubouchi, Masaaki Takashina, Masumi Umezawa, Takuya Nomura, Masaki Shimizu, Yoshiaki Kuwana, Jiro Fujimoto, Shinichi Shimizu, Kazuhiko Ogawa

＜学会誌等＞

Anticancer Research March 2025,45(3):955-963

 

＜タイトル＞

Quantitative Assessment of Delivered Dose in Carbon Ion Spatially Fractionated Radiotherapy (C-SFRT) and Biological Response to C-SFRT

＜著者＞

Toshiro Tsubouchi, Misato Umemura, Kazumasa Minami, Noriaki Hamatani, Naoto Saruwatari, Masaaki Takashina, Masashi Yagi, Keith M Furutani, Shinichi Shimizu, Tatsuaki Kanai

＜学会誌等＞

Biomed. Phys. Eng. Express 11,027002

 

＜タイトル＞

Ultra-high dose rate (FLASH) carbon ion irradiation inhibited immune suppressive protein expression on Pan02 cell line

＜著者＞

Shohei Katsuki, Kazumasa Minami, Karin Oniwa, Masashi Yagi, Shinichi Shimizu, Noriaki Hamatani, Masaaki Takashina, Tatsuaki Kanai, Kazuhiko Ogawa

＜学会誌等＞

J. Radiat. Res. Jan 22;66(1):97-102

 

＜タイトル＞

Three-dimensional Patient-specific Quality Assurance Using Beam Delivery Log Data for Pencil Beam Scanning Carbon-ion Radiotherapy

＜著者＞

Masaaki Takashina, Masashi Yagi, Yuuki Noguchi, Taku Nakaji, Noriaki Hamatani, Toshiro Tsubouchi, Tatsuaki Kanai

＜学会誌等＞

In Vivo November 2024, 38 (6) 2935-2944

 

＜タイトル＞

Investigation of Ionization Chamber Characteristics for Ultrahigh-dose-rate Scanned Carbon-ion Beams

＜著者＞

Noriaki Hamatani, Masashi Yagi, Shinichi Shimizu, Naoki Ishino, Masaki Shimizu, Yoshiaki Kuwana, Toshiro Tsubouchi, Masaaki Takashina, Takuto Miyoshi, Takuya Nomura, Takashi Toyoda, Masumi Umezawa, Teiji Nishio, Masahiko Koizumi, Kazuhiko Ogawa, Tatsuaki Kanai

＜学会誌等＞

In Vivo September 2024, 38 (5) 2220-2227

 

＜タイトル＞

Assessing the robustness of dose distributions in carbon ion prostate radiotherapy using a fast dose evaluation system

＜著者＞

Toshiro Tsubouchi, Hiroya Shiomi, Osamu Suzuki, Noriaki Hamatani, Masaaki Takashina, Masashi Yagi, Yushi Wakisaka, Atsuhiro Ogawa, Ayumi Terasawa, Yuichi Akino, Kazuhiko Ogawa, Tatsuaki Kanai

＜学会誌等＞

J. Appl. Clin. Med. Phys. 26:e14528 (2025)

 

＜タイトル＞

Dosimetric impact of stopping power for human bone porosity with dual-energy computed tomography in scanned carbon-ion therapy treatment planning

＜著者＞

Masashi Yagi, Yushi Wakisaka, Jun Takeno, Shintaro Kanada, Toshiro Tsubouchi, Noriaki Hamatani, Hiroyasu Maruo, Masaaki Takashina, Takayoshi Ishii, Tatsuaki Kanai, Shinichi Shimizu, Kazuhiko Ogawa

＜学会誌等＞

Scientific Report 14, 17440 (2024)

 

＜タイトル＞

Carbon ion therapy for laterally located tumors require multiple fixed ports or a rotating gantry

＜著者＞

Masashi Yagi, Chris J Beltran, Shinichi Shimizu, Noriaki Hamatani, Toshiro Tsubouchi, Masaaki Takashina, Tatsuaki Kanai, Kazuhiko Ogawa, Keith M Furutani

＜学会誌等＞

Med. Dosim. 49(4):279-290 (2024)

 

＜タイトル＞

Development and characterization of a dedicated dose monitor for ultrahigh-dose-rate scanned carbon-ion beams

＜著者＞

Masashi Yagi, Shinichi Shimizu, Noriaki Hamatani, Takuto Miyoshi, Takuya Nomura, Takashi Toyoda, Mahoro Nakatani, Toshiro Tsubouchi, Masaki Shimizu, Yoshiaki Kuwana, Masumi Umezawa, Masaaki Takashina, Teiji Nishio, Masahiko Koizumi, Kazuhiko Ogawa, Tatsuaki Kanai

＜学会誌等＞

Scientific Report 14, 11574 (2024)

 

＜タイトル＞

腎癌の治療　放射線療法　「粒子線治療」

＜著者＞

鈴木　修

＜学会誌等＞

日本臨床　増刊号　臨床腎・泌尿器癌（上）406-411.2024

 

＜タイトル＞

A case of pelvic EWSR1-PATZ1 fusion sarcoma treated with carbon ion radiotherapy

＜著者＞

Yagi T, Suzuki O, Matsuoka H, Shinyashiki K, Wakamatsu T, Tamiya H, Suzuki R, Kakunaga S, Takenaka S, Hashii Y, Yoshida KI, Nakanishi K.

＜学会誌等＞

Radiol Case Rep. 19(7):2674-2678.2024

 

＜タイトル＞

Assessing the robustness of dose distributions in carbon ion prostate radiotherapy using a fast dose evaluation system.

＜著者＞

Tsubouchi T, Shiomi H, Suzuki O, Hamatani N, Takashina M, Yagi M, Wakisaka Y, Ogawa A, Terasawa A, Akino Y, Ogawa K, Kanai T.

＜学会誌等＞

J Appl Clin Med Phys. 26(1) e14528.2025

 

＜タイトル＞

Dosimetric characteristics of self-expandable metallic and plastic stents for transpapillary biliary decompression in external beam radiotherapy.

＜著者＞

Yoshihiro Ueda, Kenji Ikezawa, Tomohiro Sagawa, Masaru Isono, Shingo Ohira, Masayoshi Miyazaki, Ryoji Takada, Takuo Yamai, Kazuyoshi Ohkawa, Teruki Teshima, Koji Konishi

＜学会誌等＞

Phys Eng Sci Med 47(4):1323-1335, 2024.

 

＜タイトル＞

Association of increasing gross tumor volume dose with tumor volume reduction and local control in fractionated stereotactic radiosurgery for unresected brain metastases.

＜著者＞

Naoyuki Kanayama, Toshiki Ikawa, Koji Takano, Hideyuki Arita, Masahiro Morimoto, Takero Hirata, Kazuhiko Ogawa, Teruki Teshima, Koji Konishi

＜学会誌等＞

Radiat Oncol 19(1) 95, 2024.

 

＜タイトル＞

Stereotactic Ablative Radiotherapy for Early-stage Lung Cancer in Patients With Left Ventricular Assist Device: A Case Series.

＜著者＞

Hayashi K, Ishikawa H, Fujiwara K, Nakai M, Ono H, Fumimoto Y, Tamaki N, Tatekawa S, Hirata T, Kimura T, Hirata H, Tamari K, Takeda Y, Shimizu S, Shintani Y, Ogawa K.

＜学会誌等＞

Anticancer Res.44(9):4113-4117.2024

 

＜タイトル＞

Prognostic analysis of radiation-induced liver damage following carbon-ion radiotherapy for hepatocellular carcinoma.

＜著者＞

Hayashi K, Suzuki O, Wakisaka Y, Ichise K, Uchida H, Anzai M, Hasegawa A, Seo Y, Shimizu S, Ishii T, Teshima T, Fujimoto J, Ogawa K.

＜学会誌等＞

Radiation Oncology 22;19(1):51.2024

 

【2023年度】

＜タイトル＞

“Validation of robust radiobiological optimization algorithms based on the mixed beam model for intensity-modulated carbon-ion therapy”

＜著者＞

M. Yagi, T. Tsubouchi, N. Hamatani, M. Takashina, T. Kanai

＜学会誌等＞

PLoS ONE 18(7): e0288545 (2023)

 

＜タイトル＞

Carbon-ion radiotherapy for oligometastatic liver disease: A national multicentric study by the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS).

＜著者＞

Shiba S, Wakatsuki M, Toyama S, Terashima K, Uchida H, Katoh H, Shibuya K, Okazaki S, Miyasaka Y, Ohno T, Tsuji H.

＜学会誌等＞

Cancer Sci. 2023 Sep;114(9):3679-3686. doi:10.1111/cas.15871. Epub 2023 Jun 30. PMID:37391921; PMCID:PMC10475754.

 

＜タイトル＞

Linear accelerator-based stereotactic radiotherapy for brain metastases, including multiple and large lesions, carries a low incidence of acute toxicities: a retrospective analysis. Radiat Oncol.

＜著者＞

Ikawa T, Kanayama N, Arita H, Ohira S, Takano K, Hirata T, Morimoto M, Teshima T, Konishi K.

＜学会誌等＞

2023 May 10;18(1):80. doi:10.1186/s13014-023-02262-z. PMID:37165431; PMCID:PMC10173492.

 

＜タイトル＞

Japanese Society For Radiation Oncology Database Committee. A JROD survey: nationwide overview of radiotherapy data from 2015 to 2021.

＜著者＞

Ohba H, Nakada Y, Numasaki H, Umehara K, Ota J, Okuda Y, Teshima T, Ogawa K, Nakamura K

＜学会誌等＞

J Radiat Res. 2023 Nov 21;64(6):904-910. doi:10.1093/jrr/rrad067. PMID: 37738418;PMCID:PMC10665294.

 

＜タイトル＞

Clinical results of carbon-ion radiotherapy for stage I non-small cell lung cancer with concomitant interstitial lung disease: a Japanese national registry study (J-CROS-LUNG).

＜著者＞

Okano N, Suefuji H, Nakajima M, Tokumaru S, Kubo N, Yoshida D, Suzuki O, Ishikawa H, Satouchi M, Nakayama H, Shioyama Y.

＜学会誌等＞

J Radiat Res. 2023 Jun 16;64(Supplement_1):i2-i7. doi:10.1093/jrr/rrad008. PMID:37036751; PMCID:PMC10278880.

 

＜タイトル＞

Particle beam therapy versus photon radiotherapy for extrahepatic biliary cancer-systemic review and meta-analysis.

＜著者＞

Yamazaki H, Kimoto T, Teramukai S, Fujikawa K, Shibuya K, Suzuki M, Terashima K, Iizumi T, Wakatsuki M, Suzuki O, Fukumoto T, Ohtsuka M.

＜学会誌等＞

J Radiat Res. 2023 Jun 16;64(Supplement_1):i34-i40. doi:10.1093/jrr/rrad015. PMID: 37036780; PMCID:PMC10278884.

 

＜タイトル＞

Increased toxicities associated with dose escalation of stereotactic body radiation therapy in prostate cancer: results from a phase I/II study. Acta Oncol.

＜著者＞

Hirata T, Suzuki O, Otani K, Miyake A, Tamari K, Seo Y, Isohashi F, Kai N, Hatano K, Fujita K, Uemura M, Imamura R, Tamenaga S, Yoshino Y, Fumimoto Y, Yoshioka Y, Nonomura N, Ogawa K.

＜学会誌等＞

2023 May;62(5):488-494. doi:10.1080/0284186X.2023.2213443. Epub 2023 May 18. PMID:37203203.

 

＜タイトル＞

Innovative Combination Treatment to Expand the Indications of Particle Therapy:Spacer Placement Surgery Using Bio-Absorbable Polyglycolic Acid Spacer.

＜著者＞

Komatsu S, Wang T, Terashima K, Demizu Y, Anzai M, Suga M, Yamashita T, Suzuki O, Okimoto T, Sasaki R, Fukumoto T.

＜学会誌等＞

J Am Coll Surg. 2024 Jan 1;238(1):119-128. doi:10.1097/XCS.0000000000000873. Epub 2023 Sep 22. PMID: 37737669.

 

＜タイトル＞

Dose Rate Effect on Cell Survival in BNCT. Curr Issues Mol Biol.

＜著者＞

Hirose K, Sato M, Ichise K, Aoki M.

＜学会誌等＞

2023 Aug 23;45(9):6986-6994. doi: 10.3390/cimb45090441. PMID:37754225; PMCID:PMC10530115.

 

＜タイトル＞

Investigation of the efficacy of the change ratio of brain natriuretic peptide for predicting the cardiac effects of chemoradiotherapy on esophageal cancer. Oncol Lett.

＜著者＞

Hatayama Y, Kudo S, Ota R, Kuroki A, Tanaka M, Yotsuya C, Ichise K, Fujioka I, Sato M, Kawaguchi H, Aoki M.

＜学会誌等＞

2023 Aug 23;26(4):439. doi:10.3892/ol.2023.14026. PMID:37664653; PMCID:PMC10472025.

 

＜タイトル＞

Hepatobiliary Oncology Group (KHBO). Randomized phase III study of gemcitabine, cisplatin plus S-1 versus gemcitabine, cisplatin for advanced biliary tract cancer (KHBO1401- MITSUBA).

＜著者＞

Ioka T, Kanai M, Kobayashi S, Sakai D, Eguchi H, Baba H, Seo S, Taketomi A, Takayama T, Yamaue H, Takahashi M, Sho M, Kamei K, Fujimoto J, Toyoda M, Shimizu J, Goto T, Shindo Y, Yoshimura K, Hatano E, Nagano H; Kansai

＜学会誌等＞

J Hepatobiliary Pancreat Sci. 2023 Jan;30(1):102-110. doi:10.1002/jhbp.1219. Epub 2022 Aug 9. PMID:35900311; PMCID:PMC10086809.

 

＜タイトル＞

Autophagy Inhibition Increased Sensitivity of Pancreatic Cancer Cells to Carbon Ion Radiotherapy.

＜著者＞

Sudo M, Tsutsui H, Hayashi S, Yasuda K, Mitani K, Iwami N, Anzai M, Tsubouchi T, Ishida M, Satoi S, Kanai T, Hirono S, Hatano E, Fujimoto J

＜学会誌等＞

Cell Physiol Biochem. 2023 Jul 19;57(4):212-225. doi:10.33594/000000639. PMID:37463410.

 

【2022年度】

＜タイトル＞

“Treatment Planning of Carbon Ion Radiotherapy for Prostate Cancer Based on Cellular Experiments with PC3 Human Prostate Cancer Cells”

＜著者＞

Yushi Wakisaka, Kazumasa Minami, Nao Okada, Toshiro Tsubouchi,Noriaki Hamatani, Masashi Yagi, Masaaki Takashina, Tatsuaki Kanai

＜学会誌等＞

Physica Medica

 

＜タイトル＞

“Ultra-high Dose-rate Carbon-ion Scanning Beam with a Compact Medical Synchrotron Contributing to Further Development of FLASH Irradiation”

＜著者＞

Masashi Yagi, Shinichi Shimizu, Kazumasa Minami, Noriaki Hamatani, Toshiro Tsubouchi, Masaaki Takashina, Masumi Umezawa, Takuya Nomura, Wataru Mukoyoshi, Teiji Nishio, Masahiko Koizumi, Kazuhiko Ogawa, and Tatsuaki Kanai

＜学会誌等＞

Anticancer Research

 

＜タイトル＞

“Clinical dose assessment for scanned carbon-ion radiotherapy using linear energy transfer measurements and Monte Carlo simulations”

＜著者＞

Taku Nakaji, Tatsuaki Kanai, Masaaki Takashina, Akihiko Matsumura, Kohei Osaki, Masashi Yagi, Toshiro Tsubouchi, Noriaki Hamatani and Kazuhiko Ogawa

＜学会誌等＞

Phys Med Biol

 

＜タイトル＞

“Commissioning a newly developed treatment planning system, VQA Plan, for fast-raster scanning of carbon-ion beams”

＜著者＞

Masashi Yagi, Toshiro Tsubouchi, Noriaki Hamatani, Masaaki Takashina,Hiroyasu Maruo, Shinichiro Fujitaka, Hideaki Nihongi, Kazuhiko Ogawa, Tatsuaki Kanai,

＜学会誌等＞

PRoS ONE. 2022;17(5):e0268087

 

＜タイトル＞

Randomized phase III study of gemcitabine, cisplatin plus S-1 versus gemcitabine, cisplatin for advanced biliary tract cancer (KHBO1401-MITSUBA).

＜著者＞

Ioka, T, Kanai M, Kobayashi S, Sakai D, Eguchi H, Baba H, Seo S, Taketomi A, Takayama T, Yamaue H, Takahashi M,Sho M, Kamei K, Fujimoto J, Toyoda M, Shimizu J, Goto T, Shindo Y, Yoshimura K,Hatano E, Nagano H.

＜学会誌等＞

J Hepatobiliary pancreat Sci. 2023, (30): 102-110

 

【2021年度】

＜タイトル＞

Commissioning of carbon-ion radiotherapy for moving targets at the Osaka Heavy-Ion Therapy Center

＜著者＞

N. Hamatani, T. Tsubouchi, M. Takashina, M. Yagi, T. Kanai

＜学会誌等＞

Med. Phys. 2021, 1-12

 

＜タイトル＞

“Carbon ion radiotherapy using fiducial markers for　prostate cancer in Osaka HIMAK: Treatment planning”

＜著者＞

T. Tsubouchi, N. Hamatani, M. Takashina, Y. Wakisaka, A. Ogawa, M. Yagi, A. Terasawa, K. Shimazaki, M. Chatani, J. Mizoe, T. Kanai

＜学会誌等＞

J Appl Clin Med Phys 2021; 22:242–251.

 

＜タイトル＞

Physical and biological beam modeling for carbon beam scanning at Osaka Heavy Ion Therapy Center

＜著者＞

S. Fujitaka, Y. Fujii, H. Nihongi, S. Nakayama, M. Takashina, N. Hamatani, T. Tsubouchi, M. Yagi, K. Minami, K. Ogawa, J. Mizoe, T. Kanai

＜学会誌等＞

J Appl Clin Med Phys 2021;22:7:77–92

 

＜タイトル＞

“Stereotactic Ablative Radiotherapy Using CyberKnife for Stage I Non-small-cell Lung Cancer: A Retrospective Analysis”

＜著者＞

KAZUHIKO HAYASHI, OSAMU SUZUKI, HIROYA SHIOMI, MASATAKA NAKAI, KEI FUJIWARA,ERINA NAKANISHI, SHOTARO TATEKAWA, TAKERO HIRATA, KEISUKE TAMARI,HARUHIKO HIRATA, SOICHIRO FUNAKI, YUJI SEO, YOSHITO TAKEDA,FUMIAKI ISOHASHI, YASUSHI SHINTANI and KAZUHIKO OGAWA

＜学会誌等＞

ANTICANCER RESEARCH (42:321-327)Jan-22　2021

 

＜タイトル＞

Immune aging and how it works for inflammation and fibrosis.

＜著者＞

Hiroshi Nishiura, Mai Imasaka, Koji Yamanegi, Jiro Fujimoto, Masaki Ohmuraya.

＜学会誌等＞

Frontiers in Phsiology, section Gastrointestinal Sciences, (In press)

 

＜タイトル＞

Antithronbin together with NETs inhibitor protected against postoperative adhesion formation in mice.

＜著者＞

Sudo M, Jinyang Xu, Keiko Mitani, Mayo Jimbo, Hiroko Tsutsui, Etsurou Hatano, Jiro Fujimoto.

＜学会誌等＞

(published online 3 July 2021) Cell Phsiol Biochem, 55, 400-412, 2021

 

【2019年度】

＜タイトル＞

A retrospective multicenter study of carbon-ion radiotherapy for external auditory canal and middle ear carcinomas.

外耳道癌および中耳癌に対する炭素イオン放射線療法のレトロスペクティブな多施設共同研究。

＜著者＞

Hayashi K, Koto M, Demizu Y, Saitoh JI, Suefuji H, Okimoto T, Ohno T, Shioyama Y, Takagi R, Ikawa H, Nemoto K, Nakano T, Kamada T.

＜学会誌等＞

Cancer Med. 2019 Jan;8(1):51-57.

 

＜タイトル＞

Clinical outcomes of carbon-ion radiotherapy for locally advanced non-small-cell lung cancer.

局所進行非小細胞肺癌に対する炭素イオン放射線療法の臨床結果

＜著者＞

Hayashi K, Yamamoto N, Nakajima M, Nomoto A, Tsuji H, Ogawa K,

＜学会誌等＞

Cancer Sci. 2019 Feb;110(2):734-741.

 

＜タイトル＞

Feasibility of Re-irradiation using carbon ions forrecurrent head and neck malignancies after carbon-ion radiotherapy

炭素イオン放射線療法後の再発性頭頸部悪性腫瘍に対する炭素イオンを使用した再照射の実行可能性

＜著者＞

Hayashi K, Koto M, Ikawa H, Hagiwara Y, Tsuji H, Ogawa K, Kamada T.

＜学会誌等＞

Radiother Oncol. 2019 Apr 19;136:148-153.